Therapeutic Area Lead (TAL), Drug Metabolism, Pharmacokinetics and Modeling (DMPK&M) (Sr. Director)

Company: Takeda
Location: Boston
Posted on: January 16, 2026

Job Description:

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job Description Objectives/Purpose: The Therapeutic Area Lead in DMPK&M will have strong scientific and strategic leadership to impact broad responsibilities on the pipeline, talent, and strategy. This role will supervise and lead a team of DMPK&M project representatives and Modeling & Simulation (M&S) scientists responsible for delivering on Takeda’s research pipeline in NS, GI2, or ONC therapeutic area. This role is responsible for oversight on the DMPK&M strategy of the respective portfolio and ensures the execution of DMPK&M project plans, translation, and dose optimization strategies, as well as review of regulatory filings. This role will participate in therapeutic area-driven discussions and partner with cross-functional stakeholders to align on Takeda’s strategic framework. Key deliverables will be contributing to portfolio strategy and global business operations within DMPK&M. Demonstrates leadership experience in guiding talented teams and is a key member of the Global DMPK&M leadership team that drives department strategy, creates a positive and effective department culture, and strengthens partnerships across the Research and Development organizations within Takeda. Scope: Leads a team of DMPK project representatives and modeling scientists who have key scientific and strategic input to research projects to enable Takeda to meet its global research goals. Accountable for strategic planning and scientific oversight of the discovery and development portfolio for their respective therapeutic area. Actively supports DMPK&M Head in strategic execution of DMPK&M Vision and Mission. Drives the development of organizational culture and capabilities by building strong alliances across the Research and Development organizations within Takeda. Scientific responsibilities: Provides scientific leadership and strategic guidance on stage-appropriate questions related to DMPK&M to ensure the selection and development of clinical candidates with optimal drug development characteristics. Builds and enhances an external network to keep a pulse on scientific developments, novel strategies, partnership opportunities, and the latest competitive and regulatory landscape, particularly in relation to specific therapeutic areas. Advises, reviews, and approves, on behalf of DMPK&M, milestone presentations and PRC narratives. Oversees and participates in regulatory activities, including the review and approval of robust and fit-for-purpose submission packages in their respective areas. Strategic responsibilities: Act as the DMPK&M functional representative in governance committees and discussions regarding prioritization, strategy, resources, timelines, and decision-making criteria. As the DMPK&M Therapeutic Area Lead, this role will facilitate the alignment of DMPK&M strategy with DDU and TAU portfolio goals. Collaborate with DDU and TAU senior leaders, communicating needs, strategy, and execution plans, while consulting with DMPK leadership to ensure resources and goals are aligned. Accountable for appropriate resourcing of project support by collaborating with the Global DMPK&M leadership team. Resources and reviews in-licensing evaluations for their respective therapeutic area. Management responsibilities: Actively attract, develop, and retain talent. Dimensions and Aspects: Technical/Functional (Line) Expertise: Comprehensive understanding of drug discovery and development, the pharmaceutical industry, DMPK&M science. Leadership: Achieves success for Takeda by collaboratively working with partners across the organization. Ability to work across functions, regions, and cultures. Functional level leadership with the ability to inspire, motivate and drive results. Excellent communicator can persuasively convey both ideas and data, verbally and in writing. Proven skills as an effective team player who can engender credibility and confidence within and outside the company. Ability to distill complex issues and ideas down to simple comprehensible terms. Demonstrates leadership presence and confidence. Embraces and demonstrates a diversity and inclusion mindset and role models these behaviors for the organization. Builds teams across functions and geographies with individuals who have the right skills and experience to deliver on key organizational initiatives. Invests time in helping others to enhance their skills and perform at a higher level. Decision-making and Autonomy: Provides input to highly complex decisions that impacts functional area. Accountable for decision making for designated function. Ability to seek diverse input from multiple constituents and stakeholders to drive innovative solutions. Ability to incorporate feedback and ensure decisions are implemented swiftly to yield flawless execution. Accountable for providing input to and implementing vision and strategy for designated scope. Interaction: Effectively navigates the changing external and internal environment and leads others through change by creating an inspiring and engaging workplace. Cultivates a broad network of relationships throughout Takeda, with affiliates and external partners, in the industry and area of expertise. Effectively represents function in negotiations with the ability to resolve conflict in a constructive manner. Ability to build strong relationships and collaborate effectively with other interfacing Takeda functions. Innovation: Forward thinking with the ability to recommend, influence on behalf of DMPK&M and implement continuous innovation. Comfortable challenging the status quo and bringing forward innovative solutions. Ability to take risks implementing innovative solutions, accelerating time to market. Complexity: Ability to work in a global ecosystem (internal and external) with a high degree of complexity. Ability to see and understand a broader, enterprise level perspective. Qualifications: Good understanding of the (NS, GI2 or ONC) DDU/TAU project portfolio, disease indications, and typical DMPK&M considerations for patients Deep drug discovery and development experience and profound DMPK&M expertise required. Experience in managing preclinical scientists and preparation of INDs, CTDs, NDAs, and MAAs. Proactive, innovative, with good problem-solving skills. Exceptional leadership, coaching, employee development skills. Ability to work strategically in a cross functional team and matrix environment. In-depth knowledge of the functional area, business strategies, and the company’s goals. Excellent written, presentation, and verbal communication skills. A track record of sustained, significant scientific contributions in DMPK and modeling, as demonstrated by publications and presentations. Education: PhD degree in a scientific discipline with 15 years experience, MS with 21 years experience, or BS with 23 years experience including at least 9 years of Industry experience in pharmaceutical DMPK and modeling Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: $208,200.00 - $327,140.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Keywords: Takeda, Springfield , Therapeutic Area Lead (TAL), Drug Metabolism, Pharmacokinetics and Modeling (DMPK&M) (Sr. Director), Science, Research & Development , Boston, Massachusetts